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Interestingly, these benefits may be blunted in the approximately 30% of patients in whom liraglutide increased the resting heart rate (HR) by 10 bpm or more (61)

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Clinicians should exercise caution until larger, carefully planned prospective trials elucidate these correlations, particularly when administering GLP-1 RAs for prolonged periods of time in individuals that are already at risk for colorectal cancers