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Retatrutide dosage escalation (Phase 2 trial protocol) The Phase 2 trial tested multiple starting dose strategies

Recently, peripheral leptin resistance especially leptin resistance in muscle, has drawn more attention, which may provide new insights into the treatment of obesity [220]

[DOI] [PMC free article] [PubMed] [Google Scholar] 94.Hsu T.M., Noble E.E., Liu C.M., Cortella A.M., Konanur V.R., Suarez A.N., Reiner D.J., Hahn J.D., Hayes M.R., Kanoski S.E

Week 1 Titration: Start with 1 mg (1000 mcg) daily to assess tolerability before advancing to 2 mg

That is why women with PCOS should be offered screening for obesity, dyslipidaemia, hypertension and diabetes and, if diagnosed, also appropriate treatment