is jardiance a glp 1 agonist GLP-1 Agonists - What it? Glucagon-like peptide 1 receptor agonists:

Any use remains off-label and unsupported by trial data

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In HFrEF, an issue remains that because GLP-1 RAs have been shown to modestly increase heart rate (2-3 beats per minute) owing to their chronotropic effects (see Mechanisms) (Sun et al., 2015), GLP-1 RA treatment in HFrEF may be problematic considering that, in line with the use of beta-blockers to ameliorate HFrEF (11, 12), heart rate elevations may result in a worse outcome (DeVore et al., 2016

Hutch CR, Sandoval D

However, recent Phase III data for the trifunctional GLP-1/GIP/Glucagon receptor agonist retatrutide show average weight loss of around 28.7%, significantly exceeding results from GLP-1 monotherapy