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MN generates low-resistance water channels in the skin, which can be further utilized by INT to increase the flux of drugs through the skin layer [98,101]
In some cases, temporary dose reduction or treatment interruption may be appropriate while addressing hydration status, with subsequent cautious re-titration once symptoms resolve
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Employers are looking at how the cost of the drug compares to potential costs that could arise from obesity comorbidities like hypertension, heart disease, Type 2 diabetes and some cancers, Stich said
