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This distributed model can create inconsistent depth of metabolic assessment and follow-up protocols

Small amounts distributed throughout the day are generally better tolerated than large quantities in a single meal, given the delayed gastric emptying associated with semaglutide therapy

[ 4 ] In practical terms

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That limitation matters because cross-trial comparisons can be distorted by: different baseline populations different dose-escalation schemes different trial duration different background lifestyle support different endpoint definitions So while it is fair to compare mechanisms and published patterns, it is not rigorous to declare a final winner