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Conclusions Subcutaneous tirzepatide and oral semaglutide may be cost-effective interventions in the first 68 weeks of treatment, having dominance over subcutaneous semaglutide and subcutaneous liraglutide in adults with obesity or overweight

Don't reuse the same spot two weeks in a row

Some people use these medications only during the first few days at each new dose level to get through the worst adjustment period

Tirzepatide works by targeting multiple pathways involved in regulating blood sugar and body weight, making it a compelling option for patients struggling with weight management

Blood glucose control may deteriorate as the medication's insulinotropic effects wane, particularly in patients with type 2 diabetes who rely on tirzepatide for glycemic management