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The early pancreatic-cancer fear has largely not held up in long-term trials and reviews (Jalleh 2026)

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Clinical trial criteria excluded a significant number of adults without diabetes eligible for GLP-1 receptor agonist treatment from studies assessing the drugs safety and efficacy, results of a research letter showed

Thus, in salivary acinar cells, cAMP/PKA/EPAC signaling plays a role analogous to pancreatic insulin release, but here it fine-tunes exocytosis of salivary proteins and enzymes rather than insulin granules

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