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Measurement of tamoxifen and metabolites Tamoxifen and its metabolites DM-Tam, ( Z )-4-hydroxytamoxifen ((Z)-4-OH-Tam), ( Z )-endoxifen, N -desmethyltamoxifen (DM-Tam), N , N -Didesmethyltamoxifen (DDM-Tam) and ( Z )-norendoxifen ((Z)-4-OH-DDM-Tam
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The test buffer selected was NaHCO 3 since the EC50 was 14.7 ng/mL, lower than that obtained with PBS, which was 55.5 ng/mL (Fig
