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The majority of GLP-1RA treatment regimens reported nausea as the most frequent gastrointestinal side effect, particularly when beginning a GLP-1 or shortly following dose

Sexual dysfunction in selective serotonin reuptake inhibitors (SSRIs) and potential solutions: a narrative literature review

And in this case its a bioavailability issue
Basal insulin therapy in type 2 diabetes: 28-week comparison of insulin glargine (HOE 901) and NPH insulin

GLP-1 meds slow stomach emptying, and that delay can stretch the onset and intensity of edibles in unpredictable ways