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Both medications are metabolized through different pathwayssemaglutide undergoes dipeptidyl peptidase-4 (DPP-4) degradation and endopeptidase breakdown, while bupropion is metabolized by the hepatic CYP2D6 enzyme system
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The challenge in establishing causality lies in distinguishing medication-related effects from coincidental occurrences
It is unclear whether using one drug over another yields differences in cardiovascular outcomes
