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Most adverse events were mild to moderate gastrointestinal events, primarily occurring during the dose-escalation period

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Mechanism In response to a previous FDA inquiry, two short-term mechanical studies were conducted using exenatide and liraglutide in a diabetic rat model, wherein one rat administered with exenatide died of pancreatic necrosis, while the others exhibited acinar-to-ductal metaplasia and ductal hyperplasia, indicative of potential premalignant alterations [62,63]

Advances in Therapy, 39 (6), 24522467