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Third, constipation and diarrhea, which represent opposing effects on bowel function, both increased with orforglipron treatment, reflecting the complex effects of GLP-1 receptor activation on gut motility, water absorption, and intestinal secretion

However, links between TRT and prostate cancer remain inconclusive

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Patients taking anticoagulant or antiplatelet medications who notice a sudden increase in bruising frequency or severity should have their medication regimen reviewed and potentially their coagulation parameters checked

Food and Drug Administration (hereinafter referred to as FDA) issued a complete response letter to Intercept, rejecting the companys new drug application for OCA as a treatment for MASH-related pre-cirrhotic liver fibrosis in June 2023 due to an unfavorable benefit/risk profile