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Surgery = One Procedure, Long-Term Benefits Bariatric surgery may have a higher upfront cost, but unlike GLP-1 medications, it: Does not require lifelong dosing Produces more durable, effective weight loss Reduces long-term healthcare costs by improving diabetes, blood pressure, sleep apnea, and more Conclusion: Bariatric surgery is both MORE effective and LESS expensive than long-term GLP-1 therapy

In the clinical study above with the most average weight loss (16%), all participants followed a low calorie diet and attended 30 behavioral counseling visits within 68 weeks

However, we did not detect germline LAG-1 ChIP-seq peaks or canonical LAG-1/CSL binding sites in these five genes, indicating that they do not fit the criteria of a primary GLP-1 signaling transcriptional target

However, more studies are needed to refine these conclusions

Upon ligand/receptor interaction the intracellular portion of GLP-1/Notch is thought to translocate to the nucleus and interact with the LAG-1 transcription factor and the SEL-8/LAG-3 transcriptional co-activator (Petcherski and Kimble, 2000)