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The exact mechanism of topiramate is not well understood, but it augments weight loss induced by phentermine through suspected modulation of GABA receptors, carbonic anhydrase inhibition, and glutamate antagonism [36]

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The mass of pancreatic fat (PF) is directly associated with the production of insulin (Yamazaki et al., 2018

5,6 Thus, new T2D pharmacotherapy guidelines have recommended the use of GLP-1RAs for prevention and treatment of obese patients with risks of atherosclerotic cardiovascular diseases, whereas SGLT-2is has been proposed for patients with a risk of chronic heart failure