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Insulin resistance is associated with metabolic dysfunction-associated steatotic liver disease (MASLD, formerly known as NAFLD), polycystic ovary syndrome (PCOS), obstructive sleep apnea, and certain metabolic-related conditions

These drugs should not be used in people with a personal or family history of medullary thyroid carcinoma or MEN2 syndrome

Weight changes , which some patients may experience as a secondary effect, generally become noticeable after 8 to 12 weeks of treatment, though this varies considerably between individuals

Phentermine/Topiramate ER Only one small trial has evaluated this combination in a PCOS population, comparing phentermine 7.5 mg plus topiramate 46 mg ER daily to exenatide 2 mg OW ( n = 36 for both arms) [171]

JAMA Cardiol 2(12):13151321 Arnold SV, Stone GW, Mack MJ, Chhatriwalla AK, Austin BA, Zhang Z et al (2020) Health status changes and outcomes in patients with heart failure and mitral regurgitation: COAPT Trial