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Newly Identified Side Effect Dysesthesia: Skin sensitivity or tingling reported in 20.9% of patients at the highest dose Other Common Side Effects Nausea: 43% Diarrhea: 33% Vomiting: 21% Retatrutide FAQs: Approval, Results, Cost & Access Is Retatrutide FDA approved as of January 2026

Mir Ali, a bariatric surgeon and medical director of MemorialCare Surgical Weight Loss Center at Orange Coast Medical Center in Fountain Valley, California

It also works through a unique amylin-based pathway, which may help preserve lean muscle mass during weight loss

But ultimately, if it's about wellness and longevity and you don't need to be single-digit body fat, we can start to look at it a little bit differently

Experts also say hormonal changes triggered by GLP-1 medications may also interfere with bone metabolism, while appetite suppression could lead to nutritional deficiencies that prevent bones from rebuilding properly