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Karakasis et al

After studying data from non-clinical studies, clinical trials, post-marketing surveillance, and medical literature, the committee found that NAION is a very rare side effect of GLP-1

1 Those trials stopped the medication abruptly with no taper and no structured habit-building support, so you could argue that weight regain was inevitable in these conditions

For the two years when Ozempic and Wegovy were recently in shortage, compounders rushed to make copies to meet the enormous demand for weight loss treatments