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Phase 3 ACHIEVE-1 trial results for orforglipron, as discussed by Rosenstock and colleagues, demonstrated that this once-daily oral small molecule GLP-1 achieved statistically significant reductions in HbA1c (1.3% to 1.6% from a baseline of 8.0%) compared to placebo in adults with type 2 diabetes

Commonly reported retatrutide side effects in trials include: Nausea (especially during dose increases) Vomiting Diarrhoea or constipation Abdominal pain or bloating Indigestion / reflux Injection-site reactions or hypersensitivity in some people So far, hair loss has not been listed as a common, direct side effect of retatrutide in clinical trial publications

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United European Gastroenterol J 2023

Glucagon-like peptide 1 analogues as adjunctive therapy for patients with type 1 diabetes: an updated systematic review and meta-analysis