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Key Effects: Kidney-Focused Regulation Acts on renal proximal tubules independently of insulin

Important context for patients weighing the cardiovascular benefit against cosmetic concerns: the cardiovascular and metabolic benefits of GLP-1 therapy substantially exceed cosmetic considerations and should not be discontinued for facial appearance reasons alone

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Glucagon receptor agonism drives significant increases in energy expenditure and hepatic fat oxidation effects that are largely independent of the insulin secretion and appetite pathways activated by GLP-1R and GIPR