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There may still be limited use under 503A compounding rules, where a medication is prepared for an individual patient based on a specific clinical indication, but that pathway is much more restricted and not designed for widespread use. Jen Manne-Goehler, MD, ScD,assistant professor of medicine at Harvard Medical School, agreed

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However, recent evidence that glucagon increases energy expenditure independently of BAT activation in humans [64] indicates that alternative mechanisms such as futile substrate cycling [65] may underlie glucagons thermogenic properties

While GLP-1 drugs were first approved to treat type 2 diabetes in 2005, the class of medications have become more popular in recent years, especially as Wegovy (semaglutide) was approved for weight loss in June 2021

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