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Patients should contact their GP, call NHS 111, or seek urgent care if they experience: Severe or persistent abdominal pain , especially if radiating to the back (may indicate pancreatitisstop Ozempic immediately and seek urgent medical attention) Persistent vomiting or inability to keep down food or fluids for more than 24 hours Signs of dehydration , including dark urine, dizziness, or reduced urination Severe constipation lasting more than three days despite laxative use Abdominal distension with fever , which may indicate infection or inflammation Blood in vomit or stools , or black, tarry stools Right upper abdominal pain, yellowing of skin/eyes, pale stools or dark urine (possible gallbladder disease, which is associated with GLP-1 receptor agonists) [1] [9] Unexplained weight loss beyond what is expected with diabetes management These symptoms may indicate serious complications such as pancreatitis, gallbladder disease, or severe dehydration that could affect kidney function

Gastroenterology 132(6):21312157 Mller TD, Adriaenssens A, Ahrn B, Blher M, Birkenfeld AL, Campbell JE et al (2025) Glucose-dependent insulinotropic polypeptide (GIP)

Even though you are not hungry, what you eat determines how much energy your body can produce

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Case reports and case series have documented instances of severe, persistent gastroparesis temporally associated with GLP-1 initiation, with some patients requiring hospitalization for refractory nausea and vomiting