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Description
A multicentre, placebo-controlled trial confirming the role of GLP1 receptor agonist semaglutide in patients with knee OA obesity

To understand the studys protocol, we mention that Sirtuin 1 (SIRT1) is a protein that regulates cellular processes, including metabolism, immune response, and aging

Providers may, in their clinical discretion, prescribe it off-label if deemed appropriate for their patient

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Semaglutide does not directly cause depression in most users
