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Around the same time, I think you remember that all of pharma was interested in obesity in the early 90s, everyone wanted to do diabetes as well as obesity, but they were separate teams and they all wanted to do small molecules, but it just happens to be so that the best idea we could find at that time was actually GLP-1, because we actually had clinical data relatively early that GLP-1 was a really good candidate as a treatment for diabetes because of the glucose sensitivity of the actions

At baseline, these remarkably effective medications are tough to get unless you have type 2 diabetes

While not commonly reported with Pendulum specifically, people sensitive to gut-brain interactions may notice temporary mood fluctuations during the adjustment period

Effects of somatostatin on human satiety

Treatments for diabetes must also be easy to implement into daily life due to the long-term nature of the disease [197]