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This trial was therefore significantly underpowered to detect a difference between groups in the primary and secondary endpoints
"While this reduced risk could be an indirect result of weight loss, there is also some evidence from preclinical studies suggesting that GLP1RAs might improve depression-related neural processes by reducing neuronal inflammation," she said
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In contrast, recommendations for treatment selection in the second-line setting have been outlined in international guidelines, such as the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD) guidelines, which inform choice of treatment according to an individuals CV and chronic kidney disease (CKD) risk [15]
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