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GLP-1 and its synthetic analogs have emerged as significant therapeutic agents for the management of metabolic disorders, merging glycemic control with weight loss through innovative structural and delivery breakthroughs

By forming a complex with bile acids that cannot be absorbed by the body, cholestyramine prevents recycling of bile acid through the process of enterohepatic recirculation
A new study provides the first clinical evidence that popular semaglutide drugs, like Ozempic or Wegovy, could slow down processes associated with biological aging.

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Given the promising results in pre-clinical models (even in the absence of T2D), a unique mechanism of action and multiple age-related reduced disease risks that have been reported with acarbose, support for clinical trials with acarbose focusing on aging-related outcomes and incorporating biological sex, age at treatment initiation, and T2D-dependence within the design is warranted.
