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Genetic variations in GLP-1 receptor (GLP1R), GIP receptor (GIPR), and appetite-regulation genes (FTO, MC4R) can predispose individuals to greater weight gain and reduced satiety signals

Rather than reproducing the peptides sprawling footprint, the small molecule tucks into a compact, mostly hydrophobic pocket in the upper portion of the helical bundle

Activation of CB1 receptors inhibits neurotransmitter release, with a predominance on GABAergic compared to glutamatergic neurons across various brain regions

This is critical cardiovascular outcomes data will likely be required for full regulatory approval

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