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Researchers have also deployed specialized protecting groups, ionicliquid linkers and hydrophobicsupportassisted methodologies to reduce impurities and improve yields (Xingbang et al

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2 Metformin (MET) is recommended as the first-line treatment for patients with T2DM due to well-established efficacy, safety, low cost, and data demonstrating a reduction in risk of cardiovascular (CV) events

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