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Tirzepatide () , , Tirzepatide ()

At week 40, the average change in HbA1c levels from the baseline was -2.40% for the 10-mg tirzepatide group and -2.34% for the 15-mg tirzepatide group, compared to -0.86% for the placebo group

References Geddes DT, Gridneva Z, Perrella SL, et al

Discontinuation due to side effects ranged from ~5% at 5 mg to ~10% at 15 mg in trials

And the anti-inflammatory, neuroprotective properties of GLP-1 receptor activation may provide cumulative benefits over time
