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In the landmark SELECT trial in 2023, the scope of GLP-1RAs was expanded to assess cardiovascular risk in patients with preexisting cardiovascular disease who were overweight or obese without type 2 diabetes [48]

This dual action may involve special neurons in the hypothalamus that are only activated when both hormones are present simultaneously

Another mechanism is that GLP-1 may reduce RGC loss indirectly by preventing Mller cell gliosis

When asked whether they finish less of the food they order in one sitting when dining out, 42% of participants said "always" or "most of the time," and 44% said "occasionally." Forty-one percent said they are "always" or "most of the time" ordering smaller portions of food overall, while 43% said they are only sometimes doing that

GLP-1 Medications Improve Sleep Quality and Energy Patients on Ozempic , Wegovy , Mounjaro , or Zepbound frequently report improved sleep quality and higher daytime energy levels