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Summary About 70% of people taking semaglutide experience nausea, so choosing low-fat, gentle textures and prioritizing protein, fiber, and fluids can reduce unwanted symptoms by up to 30%

For most women on GLP-1s, the primary goal should be to maintain muscle mass while losing fat

This increases: hepatic fat oxidation energy expenditure triglyceride mobilization References: Habegger KM et al., Nature Medicine , 2010 Kim T et al., Cell Metabolism , 2018 Clinical Trial Evidence Obesity (Phase 2) Key outcomes: up to 24% body weight reduction majority of weight loss from fat mass Reference: Type 2 Diabetes Observed effects: HbA1c reduction improved glycemic control reduced insulin resistance Reference: Body Composition Effects Retatrutide appears to: reduce visceral adipose tissue reduce hepatic steatosis preserve lean mass when combined with resistance training Reference: Gastaldelli A et al., Diabetes , 2020 Neurological Research Context GLP-1 receptors are expressed in multiple brain regions including: hippocampus hypothalamus cortex These pathways may influence: neuroinflammation neuronal energy metabolism cognitive signaling Reference: Hlscher C, Nature Reviews Neuroscience , 2014 Cardiovascular and Renal Effects Incretin therapies have demonstrated: improved endothelial function reduced systemic inflammation lower cardiovascular risk markers Reference: Marso SP et al., NEJM , 2016 Safety and Tolerability Common adverse events in trials include: nausea vomiting diarrhea constipation These are generally dose-dependent and improve with titration

More approvals could push prices to Tier 3 Health Canada is currently reviewing seven other submissions for generic semaglutide by different companies and expects to make regulatory decisions on more of these submissions in the coming weeks and months [Source: canada.ca/en/health-canada/news/2026/05/canada-approves-second-generic-semaglutide-the-first-g7-country-to-do-so.html]