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The results were disappointing at that time, but once it became possible to measure insulin, researchers documented the so-called incretin effect, whereby insulin secretion is increased by oral ingestion of glucose to a greater extent than with intravenous injection

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And I feel guilty for that because it isn't due to poor performance on my husband's part," she said

3.3 Mitochondrial dysfunction and oxidative stress Chronic hyperglycemia in patients with T2DM leads to peripheral insulin resistance, whereas impaired insulin signaling pathways in the brains of patients with AD lead to brain insulin resistance, both of which are closely related to mitochondrial dysfunction and OS (Du et al., 2022