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In the MitoPark mouse, one of the few preclinical models of progressive PD, a clinically translatable dose of exendin-4 reduced the rate of dopaminergic neuronal loss and accompanying motor dysfunction (150), and mitigated mitochondrial dysfunction and loss (151)

However, side effects such as gastrointestinal discomfort and mild hypoglycemia were common, and all GLP-1 are categorized as pregnancy Category C by the U.S

No GLP-1 supplement contains semaglutide, tirzepatide, or any pharmaceutical GLP-1 drug

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