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Long-term Safety Considerations The long-term safety profile observed in the SELECT study is consistent with previously reported semaglutide studies, with no new safety concerns identified for once-weekly semaglutide 2.4 mg [54]

In isolated rat islets and in mouse insulinoma beta TC-1 cells, Exendin-4 stimulated the glucose-induced insulin secretion in a dose dependent manner [2]

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These can include nutrient deficiencies due to the restrictive nature of the diet, keto flu (symptoms of which may include headache, fatigue, and irritability) as the body adjusts to ketosis, and potential long-term health impacts related to high saturated fat intake, such as increased risk of heart disease