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bupropion is weight-neutral or promotes loss Long-term antidepressant use increases type 2 diabetes risk by 17-34%, with higher risk for TCAs and certain SSRIs/SNRIs Weight gain is most pronounced during active treatment and tends to normalize after cessation For high-risk patients, bupropion and agomelatine are metabolically preferred options Structured monitoring protocols can detect early metabolic changes before they become serious Effective interventions exist: lifestyle modifications, adjunctive medications like metformin or GLP-1 agonists You can treat depression effectively while protecting metabolic health with the right approach If youve gained weight on an antidepressant and felt frustrated, confused, or even gaslit when you tried to talk about it this article is for you

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Bioavailability differences between sites Bioavailability refers to the percentage of a medication that actually reaches your bloodstream and becomes active in your body