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Compared with placebo, tirzepatide 15 mg was the most efficacious treatment in reducing HbA 1c (mean difference 21.61 mmol/mol [1.96%]) followed by tirzepatide 10 mg (20.19 mmol/mol [1.84%]), semaglutide 2.0 mg (17.74 mmol/mol [1.59%]), tirzepatide 5 mg (17.60 mmol/mol [1.60%]), semaglutide 1.0 mg (15.25 mmol/mol [1.39%]) and semaglutide 0.5 mg (12.00 mmol/mol [1.09%])