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Open Access ARTICLE Early GLP-1 Agonist Use and Cancer Risk in Type 2 Diabetes: A Real-World Data Cohort Study 1 Institute of Medicine, Chung Shan Medical University, Taichung, 402, Taiwan 2 Department of Emergency Medicine, School of Medicine, Chung Shan Medical University, Taichung, 402, Taiwan 3 Department of Emergency Medicine, Chung Shan Medical University Hospital, Taichung, 402, Taiwan 4 Department of Internal Medicine, Zuoying Armed Forces General Hospital, Kaohsiung, 813, Taiwan 5 Department of Emergency Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, 114, Taiwan 6 Graduate Institute of Aerospace and Undersea Medicine, College of Biomedical Sciences, National Defense Medical University, Taipei, 114, Taiwan 7 Department of Orthopedic Surgery, Chung Shan Medical University Hospital, Taichung, 402, Taiwan 8 School of Medicine, Chung Shan Medical University, Taichung, 402, Taiwan 9 Department of Medical Research, Chung Shan Medical University Hospital, Taichung, 402, Taiwan * Corresponding Authors: Yu-Hsun Wang

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Recent investigations confirm that multi-receptor agonism (tirzepatide) significantly upregulates the BDNF-TrkB axis through CREB activation, providing robust protection against neurodegeneration [40]

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Key considerations for love handle injections include: Adequate subcutaneous tissue depth Absence of excessive scarring or skin changes Proper technique according to the Instructions for Use Individual body composition and comfort with accessing this area Avoiding areas that may be irritated by clothing or belt lines There is no evidence suggesting that injection in the lateral abdominal area produces different efficacy or safety outcomes compared to other approved sites, provided proper subcutaneous technique is maintained
