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Methods The Swedish Institute for Health Economics Diabetes Cohort Model was used to assess the cost effectiveness of oral semaglutide 14 mg versus empagliflozin 25 mg and oral semaglutide 14 mg versus sitagliptin 100 mg, using data from the head-to-head PIONEER 2 and 3 trials, respectively, in which these treatments were added to metformin ( sulphonylurea)

VK-2735 is a novel dual glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide (GLP-1/GIP) receptor agonist.

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Retatrutide is a single molecule that acts as a triple agonist for GLP-1, GIP, and glucagon receptors, designed to improve metabolic health beyond simple caloric restriction

The answer is nuanced: most people benefit from continuing both medications under medical supervision, as they work through different mechanisms to improve blood sugar control and promote weight loss