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This work was supported by the Robert Bosch Foundation, Stuttgart, Germany, Deutsche Forschungsgemeinschaft (DFG, SCHR 1323/2-1 and MU 1727/2-1), Germany and IZEPHA (Grant 21-0-0), Germany, The German Cancer Consortium (DKTK), American University of Beirut Medical Practice Plan (AUBMPP), and National Medical Research Council Grant NMRC/1159/2008 and NMRCG13161