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Up to 20% of users experience nausea, vomiting, diarrhea, or abdominal pain, often leading to dose adjustments or discontinuation
The confusion around dose timing is understandable
This is particularly challenging for peptide-based biologics like glucagon-like peptide-1 (GLP-1), which have low circulating levels and require high sensitivity in complex biological matrices
Zhang Y, Sun B, Feng D et al (2017) Cryo-EM structure of the activated GLP-1 receptor in complex with a G protein
