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In mice GLP-1R is expressed in the atrium of the heart and GLP-1R agonist promotes the secretion of atrial natriuretic peptide [17], which consequently causes diuresis and natriuresis

A 2023 study shows it activates enzymes that improve insulin sensitivity and reduce glucose production in the liver

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For example, if baseline HbAc was 8.5%, it might drop to ~7.5%

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