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significant weight reduction (~ 710%) through calorie restriction, with or without exercise, and bariatric/metabolic surgery results in high turnover bone loss

It activates a distributed network of neurons throughout the CNS (Gabery et al., 2020) with most of these being secondary rather than primary targets expressing GLP1 receptors

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Dual agonists that activate both GLP-1 and GIP receptors tend to cause these side effects slightly more frequently than pure GLP-1 agonists