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Furthermore, leptin receptor-deficient mice, a mouse model of obesity and diabetes, and people with endogenous glucagon deficiency (pancreatectomised individuals) treated with glucagon antisense oligonucleotide have increased hepatic fat [52, 53]
With its dual-action approach targeting both GLP-1 and GIP receptors, tirzepatide can offer enhanced appetite control, improved insulin sensitivity, and, for some, greater overall weight loss
Each of these medications has its unique properties and dosing schedules
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