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Your prescriber may consider: Ondansetron (Zofran) 4 to 8 mg as needed, particularly during the 48-hour post-dose window Dose-escalation slowdown , staying at the current semaglutide dose for an additional 4 weeks before stepping up Temporary dose reduction , returning to the previous tolerated dose The STEP 1 trial reported that 4.3% of patients on semaglutide 2.4 mg discontinued due to GI adverse events

Some users report changes in floweither lighter or heavierthough this varies by individual

Eating balanced, frequent meals, staying hydrated, maintaining good sleep routines, adding light activity, and managing stress can all make a noticeable difference

Treatment adequacy is assessed with thyroid-stimulating hormone (TSH) testing, a standard biomarker [1922]

discussion 887-8, 1999