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In agreement with expectations, the first outcome trial of a GLP-1RA, the ELIXA trial of the short-acting lixisenatide, an exendin-4 derivative with properties almost identical to those of exendin-4 or exenatide (stable, full agonists of the GLP-1 receptor), showed no increased cardiovascular risk in a patient group with severely increased CVD risk

Currently, this GGG tri-agonist is in phase two clinical trials to determine its efficacy in the treatment of obesity and type 2 diabetes

The Danish pharma company is also developing a more potent obesity treatment called CagriSema

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In this context, recent EULAR Points to Consider emphasize the importance of recognizing clinical and imaging features suggestive of progression from PsO to PsA, including arthralgia, enthesitis, subclinical synovitis on ultrasound or MRI, and elevated inflammatory markers (12)