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Among the biggest concerns are fatigue and the potential for lean muscle loss

GLP-1 users are women Higher nausea in women Hip bone density loss (52 weeks) Lean muscle mass lost The Hidden Side Effects Women Are Experiencing A 2026 study analyzing over 410,000 Reddit posts from GLP-1 users identified several "hidden" side effects that disproportionately affect women: Menstrual irregularities: Changes in cycle length, flow, timing, ovulation patterns Hot flashes and temperature dysregulation: GLP-1s affect the hypothalamus (regulates hormones and temperature) Vaginal dryness and discomfort: Rapid weight loss, dehydration, hormonal shifts Changes in libido: Variable (decreased or improved based on metabolic health) Pelvic floor dysfunction: Constipation (common GLP-1 effect) worsens symptoms Fertility changes: PCOS patients see improved ovulation

therefore, they differ slightly in emphasis from corresponding recommendations in the 2020 ADA Standards of Care

doi: 10.1523/JNEUROSCI.2773-06.2006 53 KuhnBSchmidAHarteneckCGudermannTSchultzG

According to a case report published in the Journal of Investigative Medicine in October 2021, a 52-year-old female taking semaglutide reported experiencing severe gastric pain, accompanied by fullness, bloating, and vomiting within one month of starting weekly injections