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Retatrutide works by activating three hormone receptors simultaneously: GLP-1 (reduces appetite and slows digestion), GIP (improves insulin sensitivity and fat distribution), and glucagon (increases energy expenditure and fat breakdown)

Your brain's hunger centers resume their previous signaling patterns, and the appetite suppression that drove your weight loss disappears

[8] [9] Comorbidities and concomitant medicines : Patients with type 2 diabetes particularly those taking insulin or sulfonylureas should discuss timing with their clinical team, as reduced appetite following injection may increase the risk of hypoglycaemia and may require dose adjustment of those medicines