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Semaglutide is currently the most prominent approved option in this class: Ozempic (semaglutide injection) licensed for type 2 diabetes management Wegovy (semaglutide 2.4 mg injection) licensed specifically for chronic weight management in adults with obesity or overweight with at least one weight-related comorbidity

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Figure 7B shows the top 20 differentially regulated genes in these pathways, depicting liraglutide-mediated upregulation in the ARH and downregulation in the PVH and LS, while the expression profile for semaglutide more closely resembled weight-matched and vehicle controls