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Proteolysis and oxidation of therapeutic proteins after intradermal or subcutaneous administration

For patients already tolerating metformin gastrointestinal side effects, injectable semaglutide may be preferable because it bypasses the gut absorption step

Conclusion Navigating your health journey while on semaglutide requires vigilance and open communication with your healthcare team

Circulating GLP-1 from diet and lifestyle has a half-life of 1-2 minutes before being inactivated in our bodies (Mozafariun et al 2025