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GLP-1RAs serve multiple medical purposes

Even though it's been growing in popularity, it's been a part of Ayurvedic medicine in India for more than 6,000 years

In keeping with the rule that bioactive peptides are cleaved from prohormones at sites consisting of two basic amino acids (13), several investigators initially predicted that bioactive GLP-1 would be a peptide of 37 amino acids beginning with histidine and ending in glycine, GLP-1(1-37)

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Its concurrent engagement of GLP-1R, GIPR, and GCGR distinguishes it structurally and pharmacologically from both selective GLP-1R agonists such as semaglutide and dual GLP-1R/GIPR agonists such as tirzepatide