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This is a major advantage
All statistical analyses were performed using SAS 9.4 (SAS Institute, Inc, Cary, NC), hazard ratios (HR) with 95% confidence interval (CI) were reported, and statistical significance was defined as a p-value of less than 0.05

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Its mechanismaffecting appetite, fullness, stomach emptying, and blood sugarexplains associated side effects

In this Review, we first discuss data from leptin-based clinical trials
